With the most advanced technology and years of experience in the protein crystallization field, Creative Biostructure now provides advanced custom Mempro™ envelope glycoprotein crystallization services, covering all experimental steps from gene to structure with an emphasis on protein purification, crystallization, structure determination and analysis. Our aim is to help customers accelerate research progress in a highly productive and cost-effective way.
Entry of enveloped viruses into their host cells requires fusion of the viral and cellular membranes, a process that is mediated by the viral envelope glycoprotein. Class I viral fusion proteins, such as influenza and human immunodeficiency virus type 1 (HIV-1), are synthesized as inactive precursor glycoproteins that assemble as trimers and are subsequently primed by proteolytic cleavage to generate the mature fusogenic spikes. These spikes on the virion surface, primed to undergo large-scale conformational changes culminating in virus-cell membrane fusion and viral entry. Therefore, the prefusion form of these envelope glycoproteins represents an important molecular target for antiviral intervention, which provides a sound basis for vaccine and drug development.