Enteric Coating

Introduction
Enteric-coated tablets are used in a variety of clinical settings to improve the efficacy and tolerability of medications. This article explores the diverse applications of enteric-coated pharmaceuticals in treating different medical conditions, highlighting their importance in modern medicine.

Gastroesophageal Reflux Disease (GERD)
Proton pump inhibitors (PPIs) are a cornerstone in the treatment of GERD, a condition characterized by acid reflux and heartburn. PPIs reduce stomach acid production, providing relief from symptoms and promoting healing of the esophagus. However, PPIs are sensitive to stomach acid and can be deactivated if released in the stomach. Enteric coatings protect PPIs from gastric acid, ensuring their release in the intestines where they can be absorbed and exert their therapeutic effect. This protection is crucial for the efficacy of PPIs, making enteric-coated formulations the preferred choice for GERD management.

Inflammatory Bowel Disease (IBD)
Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract. Medications for IBD, such as mesalamine, need to reach the site of inflammation in the intestines to be effective. Enteric coatings enable the targeted delivery of these drugs to the intestines, bypassing the stomach and reducing systemic absorption. This targeted approach minimizes side effects and enhances the drug’s therapeutic impact, making enteric-coated tablets a valuable option for IBD treatment.

Pain Management
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain relief and inflammation management. However, NSAIDs can cause gastrointestinal irritation, ulcers, and bleeding when released in the stomach. Enteric-coated NSAIDs mitigate these risks by preventing the release of the drug in the stomach, allowing it to dissolve in the intestines instead. This protective measure makes enteric-coated NSAIDs safer for long-term use, especially for patients with a history of gastric issues.

Enteric Coating